If you’re looking to step up your anti-aging skincare routine, allow us to introduce you to argireline. Dubbed “botox in a bottle” by TikTok, science-backed research has shown that the ingredient is known to help smooth wrinkles — it’s much cheaper, of course, and requires no needles. . “Argireline is the brand name for the peptide acetyl hexapeptide-3, also known as acetyl hexapeptide-8,” says Dr. Alexis Parcells, MD, a board-certified plastic surgeon in New Jersey and M.D. founded SUNNIE, a skin care and anti-aging clinic and Parcells Plastic Surgery company. “Peptides are important building blocks for proteins like collagen and elastin. Although commonly found in skin care products, argireline was the first peptide designed to reduce muscle movement and, therefore, reduce the appearance of wrinkles. “

According to Dr. Parcells, argireline is actually a fragment of SNAP-25, a substrate of botulinum toxin, so comparing it to botox is not just an exaggeration, as both act at the point level. nerve to muscle to prevent contraction. “When applied, it inhibits the nerves that stimulate facial movement,” she says. “Additionally, argireline has been shown to promote and optimize collagen function, resulting in firmer and more hydrated skin.” Specifically, a study published in the International Journal of Cosmetic Science found that when argireline was used daily at a 5% concentration for 28 days, it reduced wrinkles by up to 30%.

Already have a bunch of other products in your beauty routine? The good news is that argireline is easy to add to any blend, whether you keep it simple or have a 10-step process. “Argireline combines well with other ingredients and is often combined with other collagen-building and anti-wrinkle peptides, such as matrixyl and formulyst, to enhance its effects,” says Dr. Jessie Cheung, dermatologist Willow is approved by the board of certification of practice in Chicago, Illinois and New York City. “Argireline can also be combined with retinol, as they have different mechanisms of action but both aid in collagen formation.” Argireline is also a great addition to hyaluronic acid. Dr. Parcells’ only advice is to avoid combining it with alcohol-based skin care products, especially if your skin is dry, so you won’t lose all of the hydration and collagen stimulation you’re getting. argireline can provide.

According to Dr. Parcells, most products containing argireline, from serums, eye creams to moisturizers, are recommended on areas of skin with deep folds or wrinkles caused by repetitive muscle movements, like like using botox. “This includes lines on the forehead, the ’11’ line between the eyebrows and around the eyes (‘crow’s feet’),” she says.You can use the argireline product of your choice without worrying about it. twice a day – morning and night on clean skin – as there are no known side effects from use at this time.However, if you have sensitive skin, Dr. Parcells recommends testing argireline on an area. small skin for a few days before applying it all over, as there is always the possibility of irritation.

A quick note: While argireline has shown promising results in clinical trials, it will never be as effective as botox at removing wrinkles, and that’s partly due to its topical application. it. “Since botox is injected into the muscle, it is more effective overall than argireline, which has to go through the skin to the muscle,” says Dr. Cheung. Dr Parcells said: “One study has suggested that when combined with another peptide, tripeptide-10-Cirtrulline, the permeability of argireline to the muscle layer may increase its benefits. All that aside, however, Dr. Parcells says that a difference in overall appearance with daily use is still possible; it won’t be as quick or dramatic as botox.

While there aren’t any major studies on how long the effects of argireline can last, it’s a great product to try if you’re someone who is resistant to needles or you just want some help with staying in between. treatment times. To find your best match, consider these five recipes as the starting point in your search.


Ordinary Argireline Solution 10%

Normal thing


TikTokers rave about this rather concentrated serum and have reason to believe it can achieve the hype, if all its 4-star reviews are any indicator. The instructions say to apply a few drops to the forehead and eye area twice daily before your heavier products, which seems easy enough to do. You can’t beat the price tag under $8, so consider this your gateway product to test your compatibility with argireline and its ability to reduce wrinkles.


Estée Lauder Perfectionist Pro Instant wrinkle filler with Tri-Polymer blend

Estee Lauder


Think of this recipe as a filter for your wrinkles – just one where you apply IRL instead of on Instagram. The product’s filling spheres instantly work their way into the cracks and crevices around your eyes and between your brows, smoothing things out a bit and brightening your skin by boosting product. collagen production in the process.


Hydroxatone AM / PM Anti-Wrinkle Complex 1 oz



If you’re looking for a more multifunctional product that contains this heroic ingredient, then this moisturizer will be right for you. Use it as a base for your skin in the morning or simply to moisturize before bed. This is one of those formulas that combine argireline with hyaluronic acid, so you can expect instant plumping in addition to softening of wrinkles over time with regular use.


Asterwood Naturals Triple Repair Matrixyl 3000 + Argireline

Asterwood Naturals

$ 36.90

Treat this serum like a drink for your face. Just a few drops at night will deliver not only argireline and its wrinkle-reducing abilities to your skin, but also matrixyl 3000, a known plumping agent, and vitamin C, which can help brighten and fade bruises. Talk about triple threat!


Peter Thomas Roth Super Size Eyes Without Wrinkles

Peter Thomas Roth


You may want to save this worthwhile eye treatment for somewhere in your exploration, when you’ve understood its benefits and are looking for more. What’s exciting about this highly concentrated formula is its blend of six neuropeptides, which includes, of course, argireline, but also matrixyl 3000. All these protein sources combine to firm and smooth the skin around the eye area. , especially reducing the appearance of crow’s feet. Contact lens wearers and sensitive people who can peek can also use this wonder product.

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